Kalogjera-Sackellares Dalma, Sackellares J Chris
Malcolm Randall VA Medical Center, University of Florida, 32610, Gainesville, FL, USA
Epilepsy Behav. 2002 Dec;3(6):510-516. doi: 10.1016/s1525-5050(02)00528-0.
Interictal depression is common in patients with epilepsy and it significantly impacts quality of life. Previous studies indicate that lamotrigine may have antidepressant properties. Thirteen adults with uncontrolled partial seizures and concomitant depression were evaluated using measures of depression [Montgomery and Asberg Depression Rating Scale (MADRS) and the MMPI Depression Scale] and anxiety [Spielberger's State-Trait Anxiety Inventory (STAI)] to test the effects of lamotrigine on mood. Evaluations after 5 weeks and again after 3 months of lamotrigine treatment demonstrated significant improvement in depression and anxiety. Mean MADRS overall scores were significantly lower than pretreatment baseline at the 5-week and 3-month evaluations. The mean MMPI Depression score was significantly lower than baseline at the 3-month evaluation. State anxiety scores were significantly reduced from baseline after 5 weeks, but not at 3 months, whereas Trait anxiety scores were reduced from baseline at the 5-week and 3-month evaluations.
发作间期抑郁在癫痫患者中很常见，并且它会显著影响生活质量。先前的研究表明，拉莫三嗪可能具有抗抑郁特性。使用抑郁量表[蒙哥马利和阿斯伯格抑郁评定量表（MADRS）和明尼苏达多相人格调查表抑郁量表]和焦虑量表[斯皮尔伯格状态-特质焦虑量表（STAI）]对13名伴有未得到控制的部分性发作及合并抑郁的成年人进行评估，以测试拉莫三嗪对情绪的影响。在拉莫三嗪治疗5周后及3个月后再次进行评估，结果显示抑郁和焦虑有显著改善。在5周和3个月的评估中，MADRS总体平均得分显著低于治疗前基线水平。在3个月的评估中，明尼苏达多相人格调查表抑郁平均得分显著低于基线水平。状态焦虑得分在5周后从基线水平显著降低，但在3个月时未降低，而特质焦虑得分在5周和3个月的评估中均从基线水平降低。
