Clements Shaun, Moore Frank L, Schreck Carl B
Oregon Cooperative Fish and Wildlife Research Unit, Oregon State University, and USGS, Corvallis, OR 97331-3803, USA.
Horm Behav. 2003 Jan;43(1):214-21. doi: 10.1016/s0018-506x(02)00027-2.
The present study investigated whether the serotonergic system is involved in mediating the behavioral effects of corticotropin-releasing hormone (CRH) in juvenile spring chinook salmon, Oncorhynchus tshawytscha. An intracerebroventricular (ICV) injection of CRH induced hyperactivity. The effect of CRH was potentiated in a dose-dependent manner by the concurrent administration of the serotonin (5-HT) selective reuptake inhibitor fluoxetine. However, administration of fluoxetine alone had no effect on locomotor activity, suggesting that the locomotor-stimulating effect of CRH is mediated by the activation of the serotonergic system. Conversely, ICV injections of the 5-HT(1A) receptor antagonist NAN-190 attenuated the effect of CRH on locomotor activity when given in combination with CRH but had no effect when administered alone. These results provide the first evidence to support the hypothesis that the effect of CRH on locomotor activity in teleosts is mediated by activating the serotonergic system.
本研究调查了血清素能系统是否参与介导促肾上腺皮质激素释放激素（CRH）对幼年春季奇努克鲑鱼（Oncorhynchus tshawytscha）行为的影响。脑室内（ICV）注射CRH会诱发多动。血清素（5-HT）选择性再摄取抑制剂氟西汀的同时给药以剂量依赖的方式增强了CRH的作用。然而，单独给予氟西汀对运动活动没有影响，这表明CRH的运动刺激作用是由血清素能系统的激活介导的。相反，脑室内注射5-HT(1A)受体拮抗剂NAN-190与CRH联合使用时会减弱CRH对运动活动的影响，但单独给药时没有影响。这些结果提供了首个证据来支持以下假设：硬骨鱼中CRH对运动活动的影响是通过激活血清素能系统介导的。
