Clements Shaun, Schreck Carl B
Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97331-3803, USA.
Behav Neurosci. 2004 Feb;118(1):191-8. doi: 10.1037/0735-7044.118.1.191.
The authors examined the control of locomotor activity in juvenile salmon (Oncorhynchus tshawytscha) by manipulating 3 neurotransmitter systems--gamma-amino-n-butyric acid (GABA), dopamine, and serotonin--as well as the neuropeptide corticotropin releasing hormone (CRH). Intracerebroventricular (ICV) injections of CRH and the GABAA agonist muscimol stimulated locomotor activity. The effect of muscimol was attenuated by administration of a dopamine receptor antagonist, haloperidol. Conversely, the administration of a dopamine uptake inhibitor (4',4"-difluoro-3-alpha-[diphenylmethoxy] tropane hydrochloride [DUI]) potentiated the effect of muscimol. They found no evidence that CRH-induced hyperactivity is mediated by dopaminergic systems following concurrent injections of haloperidol or DUI with CRH. Administration of muscimol either had no effect or attenuated the locomotor response to concurrent injections of CRH and fluoxetine, whereas the GABAA antagonist bicuculline methiodide potentiated the effect of CRH and fluoxetine.
作者通过操纵三种神经递质系统——γ-氨基丁酸（GABA）、多巴胺和血清素——以及神经肽促肾上腺皮质激素释放激素（CRH），研究了幼年虹鳟（Oncorhynchus tshawytscha）的运动活动控制。脑室内（ICV）注射CRH和GABAA激动剂蝇蕈醇可刺激运动活动。给予多巴胺受体拮抗剂氟哌啶醇可减弱蝇蕈醇的作用。相反，给予多巴胺摄取抑制剂（4',4''-二氟-3-α-[二苯甲氧基]托烷盐酸盐[DUI]）可增强蝇蕈醇的作用。他们没有发现证据表明在同时注射氟哌啶醇或DUI与CRH后，CRH诱导的多动是由多巴胺能系统介导的。注射蝇蕈醇对同时注射CRH和氟西汀的运动反应要么没有影响，要么会减弱，而GABAA拮抗剂甲碘化荷包牡丹碱可增强CRH和氟西汀的作用。
