Clements S, Schreck C B
Oregon Cooperative Fish and Wildlife Research Unit, Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97331-3803, USA.
Comp Biochem Physiol A Mol Integr Physiol. 2007 May;147(1):43-9. doi: 10.1016/j.cbpa.2006.11.011. Epub 2006 Nov 28.
The present study investigated: 1) the behavioral effects of chronic administration of a serotonin uptake inhibitor (fluoxetine) in juvenile Chinook salmon, Oncorhynchus tshawytscha and, 2) whether chronic administration of fluoxetine alters the behavioral effects of corticotropin-releasing hormone (CRH). Chronic (20 day) treatment with fluoxetine decreased locomotor activity when compared to fish given long-term injections of saline. An intracerebroventricular (i.c.v.) injection of CRH had no effect on locomotor activity following a 20 day intraperitoneal treatment with either saline or fluoxetine. Chronic treatment with fluoxetine also increased the amount of time fish spent near the center of the tank. A similar increase was seen in fish given a chronic intraperitoneal (i.p.) series of saline followed by an acute i.c.v. injection of CRH. However, the effect was not additive when fish were given chronic i.p. injections of fluoxetine followed by an acute i.c.v. injection of CRH. These results provide evidence to support the hypothesis that the serotonergic system is involved in mediating locomotor activity and habitat choice in teleosts.
1）慢性给予5-羟色胺摄取抑制剂（氟西汀）对幼年奇努克鲑鱼（Oncorhynchus tshawytscha）行为的影响，以及2）慢性给予氟西汀是否会改变促肾上腺皮质激素释放激素（CRH）的行为效应。与长期注射生理盐水的鱼相比，氟西汀的慢性（20天）治疗降低了运动活性。在腹腔注射生理盐水或氟西汀20天后，脑室内（i.c.v.）注射CRH对运动活性没有影响。氟西汀的慢性治疗还增加了鱼在水箱中心附近停留的时间。在慢性腹腔（i.p.）注射生理盐水后再进行急性脑室内注射CRH的鱼中也观察到了类似的增加。然而，当鱼慢性腹腔注射氟西汀后再进行急性脑室内注射CRH时，这种效应并非相加的。这些结果提供了证据支持以下假设：血清素能系统参与调节硬骨鱼的运动活性和栖息地选择。
