Keaney John F, Larson Martin G, Vasan Ramachandran S, Wilson Peter W F, Lipinska Izabella, Corey Diane, Massaro Joseph M, Sutherland Patrice, Vita Joseph A, Benjamin Emelia J
Evans Memorial Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA.
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9. doi: 10.1161/01.ATV.0000058402.34138.11. Epub 2003 Jan 30.
To determine the clinical conditions associated with systemic oxidative stress in a community-based cohort. Information regarding cardiovascular risk factors associated with systemic oxidative stress has largely been derived from highly selected samples with advanced stages of vascular disease. Thus, it has been difficult to evaluate the relative contribution of each cardiovascular risk factor to systemic oxidative stress and to determine whether such risk factors act independently and are applicable to the general population.
We examined 2828 subjects from the Framingham Heart Study and measured urinary creatinine-indexed levels of 8-epi-PGF2alpha as a marker of systemic oxidative stress. Age- and sex-adjusted multivariable regression models were used to assess clinical correlates of oxidative stress. In age- and sex-adjusted models, increased urinary creatinine-indexed 8-epi-PGF2alpha levels were positively associated with female sex, hypertension treatment, smoking, diabetes, blood glucose, body mass index, and a history of cardiovascular disease. In contrast, age and total cholesterol were negatively correlated with urinary creatinine-indexed 8-epi-PGF2alpha levels. After adjustment for several covariates, decreasing age and total/HDL cholesterol ratio, sex, smoking, body mass index, blood glucose, and cardiovascular disease remained associated with urinary 8-epi-PGF2alpha levels.
Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease.
确定社区队列中与全身氧化应激相关的临床状况。关于与全身氧化应激相关的心血管危险因素的信息，很大程度上来自患有晚期血管疾病的高度选择性样本。因此，很难评估每个心血管危险因素对全身氧化应激的相对贡献，也难以确定这些危险因素是否独立起作用以及是否适用于一般人群。
我们对弗雷明汉心脏研究中的2828名受试者进行了检查，并测量了以尿肌酐为指标的8-表-前列腺素F2α水平，作为全身氧化应激的标志物。使用年龄和性别调整的多变量回归模型来评估氧化应激的临床相关性。在年龄和性别调整模型中，以尿肌酐为指标的8-表-前列腺素F2α水平升高与女性、高血压治疗、吸烟、糖尿病、血糖、体重指数以及心血管疾病史呈正相关。相比之下，年龄和总胆固醇与以尿肌酐为指标的8-表-前列腺素F2α水平呈负相关。在对多个协变量进行调整后，年龄降低、总胆固醇/高密度脂蛋白胆固醇比值降低、性别、吸烟、体重指数、血糖和心血管疾病仍与尿8-表-前列腺素F2α水平相关。
吸烟、糖尿病和体重指数与以肌酐为指标的尿8-表-前列腺素F2α水平所确定的全身氧化应激高度相关。体重指数的影响受血糖和糖尿病的影响最小，这可能表明氧化应激在肥胖对心血管疾病的有害影响中起重要作用。
