Fiehn W, Seiler D, Kuhn E, Bartels D
Eur J Clin Invest. 1975 Jul 29;5(4):327-30. doi: 10.1111/j.1365-2362.1975.tb00461.x.
20,25-Diazacholesterol, known to induce myotonia in skeletal muscle, also affects cardiac muscle as can be concluded from the development of cardiomegaly. At the same time (Na+, K+) ATPase of cardiac sarcolemmal membranes of the 20,25-diazacholesterol treated rats showed an increased activity as compared with control animals (91 percent and 46 percent stimulation respectively). The Ca++ stimulated ATPase showed the same tendency (96 percent and 64 percent stimulation). In the plasma of the treated rats creatine phosphokinase activity was found to be elevated whereas the amount of protein-bound iodine was decreased, a finding that is common in myotonic dystrophy.
已知20,25 - 二氮杂胆固醇可诱发骨骼肌肌强直，从心脏肥大的发展情况可推断它也会影响心肌。同时，与对照动物相比，经20,25 - 二氮杂胆固醇处理的大鼠心肌肌膜的（钠 +，钾 +）ATP酶活性有所增加（分别刺激91%和46%）。钙刺激的ATP酶也呈现相同趋势（刺激96%和64%）。在处理过的大鼠血浆中，发现肌酸磷酸激酶活性升高，而蛋白结合碘的量减少，这是强直性肌营养不良中的常见发现。
