Reversible inhibition of (Na+ + K+)-ATPase with a cardiac glycoside.
作者信息
Ross C R, Pessah N I
出版信息
Eur J Pharmacol. 1975 Aug;33(1):223-6. doi: 10.1016/0014-2999(75)90162-4.
PMID:126168
Abstract
The effect of a semisynthetic cardiac glycoside, Actinogen (Ay22241), on Na+ + K+ - ATPase was studied. Ay22241 was found to be as an effective inhibitor of the enzyme as ouabain, Ay22241 inhibition was a time dependent process and was completely reversible. While ouabain inhibition was also time dependent, it was only partially reversible. This reversibility with Ay22241 should make it a useful tool in studying the mode of action of cardiac glycosides.
摘要
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