Muñoz Manuel J
Laboratorio Andaluz de biologi;a, Universidad Pablo de Olavide, Carretera de Utrera Km1, 41013, Seville, Spain.
Mech Ageing Dev. 2003 Jan;124(1):43-8. doi: 10.1016/s0047-6374(02)00168-9.
Aging is the most complex phenotype for a multicellular organism. This process is now being under severe investigation. Here I will review the different processes known to affect longevity in the nematode Caenorhabditis elegans and their relationship with thermotolerance. All the longevity mutants that have been tested so far show an increase in stress resistance. In particular, long-lived mutants affected in the IGF/insulin pathway and those affected in the germ-line formation are both thermotolerant and long-lived. The mechanisms that activate the stress resistance are now been understood including the DAF-16 fork head transcription factor transport to the nucleus and the activation of genes involved in the defense to stress. The high correlation between stress resistance and longevity suggests that the same molecular activities that defend the cell from stress can defend the cell from the damage caused by aging.
衰老对于多细胞生物而言是最复杂的表型。目前这一过程正在接受深入研究。在此，我将综述已知影响线虫秀丽隐杆线虫寿命的不同过程及其与耐热性的关系。迄今为止所测试的所有长寿突变体均表现出抗逆性增强。特别是，在胰岛素样生长因子/胰岛素信号通路中受影响的长寿突变体以及在生殖系形成中受影响的突变体，既耐热又长寿。目前已经了解了激活抗逆性的机制，包括DAF-16叉头转录因子转运至细胞核以及参与应激防御的基因的激活。抗逆性与长寿之间的高度相关性表明，保护细胞免受应激的相同分子活动也可以保护细胞免受衰老造成的损伤。
