Cheng Dominic T, Knight David C, Smith Christine N, Stein Elliot A, Helmstetter Fred J
Department of Psychology, University of Wisconsin-Milwaukee, 53201, USA.
Behav Neurosci. 2003 Feb;117(1):3-10. doi: 10.1037//0735-7044.117.1.3.
Although laboratory animal studies have shown that the amygdala plays multiple roles in conditional fear, less is known about the human amygdala. Human subjects were trained in a Pavlovian fear conditioning paradigm during functional magnetic resonance imaging (fMRI). Brain activity maps correlated with reference waveforms representing the temporal pattern of visual conditional stimuli (CSs) and subject-derived autonomic responses were compared. Subjects receiving paired CS-shock presentations showed greater amygdala activity than subjects receiving unpaired CS-shock presentations when their brain activity was correlated with a waveform generated from their behavioral responses. Stimulus-based waveforms revealed learning differences in the visual cortex, but not in the amygdala. These data support the view that the amygdala is important for the expression of learned behavioral responses during Pavlovian fear conditioning.
尽管实验动物研究表明杏仁核在条件性恐惧中发挥多种作用，但对人类杏仁核的了解较少。在功能磁共振成像（fMRI）期间，人类受试者接受了经典条件性恐惧训练范式。将与代表视觉条件刺激（CSs）时间模式的参考波形以及受试者自主反应相关的大脑活动图进行了比较。当大脑活动与由其行为反应生成的波形相关时，接受配对CS-电击呈现的受试者比接受非配对CS-电击呈现的受试者表现出更大的杏仁核活动。基于刺激的波形揭示了视觉皮层的学习差异，但在杏仁核中未发现。这些数据支持了这样一种观点，即杏仁核在经典条件性恐惧训练期间对习得行为反应的表达很重要。
