Bracci-Laudiero Luisa, Celestino Domenico, Starace Giuseppe, Antonelli Alessia, Lambiase Alessandro, Procoli Annabella, Rumi Carlo, Lai Marco, Picardi Alessandra, Ballatore Giovanna, Bonini Sergio, Aloe Luigi
Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx 15/43, 00137 Rome, Italy.
J Neuroimmunol. 2003 Mar;136(1-2):130-9. doi: 10.1016/s0165-5728(03)00007-9.
In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity.
在本研究中，我们调查了人类脐带血中存在的造血干细胞（HSC）和祖细胞是否能表达神经生长因子（NGF）特异性受体TrkA和p75。我们的结果显示，脐带血CD34(+)细胞中TrkA和NGF有明显表达。TrkA和NGF的表达存在梯度，在脐带血CD34(+)细胞中最高，在脐带血单个核细胞（MNC）中降低，而在从成人外周血分离的单个核细胞中最低。我们的发现表明，NGF可能在造血祖细胞的分化中起作用，并表明免疫细胞对NGF的需求因其成熟状态而异。
