Three chromosome abnormalities (trisomy 21, XXY, and a de nova reciprocal translocation) in a child with 48, XXY, + 21,T(6;10)(P22-24;P12).

An infant with chromosomally normal parents was found to have double aneuploidy and a reciprocal translocation between chromosomes number 6 and 10. This cooccurrence may represent a very rare coincidence or may indicate that primary nondisjunction and chromosome rearrangements may be more than coincidentally related.