Yuen T G, Agnew W F, Rumbaugh C L
Invest Radiol. 1976 Mar-Apr;11(2):112-24. doi: 10.1097/00004424-197603000-00006.
Electron microscope evaluation of choroid plexus and ependyma following single cerebral intraventricular injections of Conray 60 and Pantopaque was carried out on 35 rats and 4 dogs. The animals were sacrificed at periods ranging from 1 hour to 4 months. Conray was not detected with the light or electron microscope; however, Pantopaque was presumptively localized as electron-dense masses associated with lipid-like bodies at the ventricular interface of both choroidal and ependymal epithelium. Conray 60 injections consistently induced convulsions in rats. Histological studies demonstrated moderate cellular damage and multilayered proliferation of ependymal epithelium. Morphological damage following Pantopaque was more severe and widespread in both choroid plexus and ependyma suggesting that, of the two agents, Conray may have the greater clinical potential provided that the associated convulsions are controlled by appropriate measures.
对35只大鼠和4只狗进行了单次脑室内注射康瑞60（Conray 60）和碘苯酯（Pantopaque）后脉络丛和室管膜的电子显微镜评估。在1小时至4个月的时间段内处死动物。用光镜或电镜均未检测到康瑞；然而，碘苯酯据推测定位为与脉络丛和室管膜上皮的心室界面处的类脂体相关的电子致密团块。康瑞60注射在大鼠中持续诱发惊厥。组织学研究显示室管膜上皮有中度细胞损伤和多层增殖。碘苯酯后的形态学损伤在脉络丛和室管膜中更严重且更广泛，这表明，在这两种药物中，如果通过适当措施控制相关惊厥，康瑞可能具有更大的临床潜力。
