Pless Misha, Chang Brian M
Neuro-Ophthalmology Division, University of Pittsburgh, Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
J Neurooncol. 2003 Jan;61(2):137-41. doi: 10.1023/a:1022175430799.
A 73-year-old woman presented with mild anterior uveitis, ipsilateral optic neuropathy, and ipsilateral skin nodules. A compressive mass at the level of the orbital apex and sphenoid wing was found on cranial magnetic resonance imaging. Biopsy of the skin nodules revealed histopathologic evidence of sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease (RDD). Systemic investigations failed to show any massive lymphadenopathy, making this a case of extranodal RDD. This is a salient case in that it proposes three simultaneous and separate sites of involvement by extranodal RDD. It also exemplifies that RDD should be a suspect diagnosis even in the absence of lymphadenopathy.
一名73岁女性出现轻度前葡萄膜炎、同侧视神经病变和同侧皮肤结节。头颅磁共振成像显示眶尖和蝶骨翼水平有一个压迫性肿块。皮肤结节活检显示有窦组织细胞增生伴巨大淋巴结病（Rosai-Dorfman病，RDD）的组织病理学证据。全身检查未发现任何巨大淋巴结病，因此这是一例结外RDD病例。这是一个突出的病例，因为它提示结外RDD同时累及三个不同的部位。它还例证了即使在没有淋巴结病的情况下，RDD也应作为可疑诊断。
