Chang Yuh-Chwen, Hsieh Pei-Wen, Chang Fang-Rong, Wu Ru-Rong, Liaw Chih-Chuang, Lee Kuo-Hsiung, Wu Yang-Chang
Department of Chemical Engineering, Kao Yuan Institute of Technology, Kaohsiung, Taiwan, ROC.
Planta Med. 2003 Feb;69(2):148-52. doi: 10.1055/s-2003-37710.
Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannular conformations of the isolated protopine-type alkaloids. The known benzo[ c]phenanthridine (+/-)-6-acetonyldihydrochelerythrine (5) exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively.
从台湾蓟罂粟（罂粟科）的甲醇提取物中分离出两种新的原托品碱型生物碱，即蓟罂粟甲素（1）和蓟罂粟乙素（2），以及13种已知生物碱。通过物理和光谱分析，特别是红外光谱以及热调制一维和二维核磁共振光谱，来确定分离出的原托品碱型生物碱的跨环构象。已知的苯并[c]菲啶（±）-6-丙酮基二氢白屈菜红碱（5）在H9淋巴细胞中表现出显著的抗HIV活性，其半数有效浓度（EC50）和治疗指数（TI）值分别为1.77μg/mL和14.6。
