地桃花中的生物碱。

Alkaloids from Melochia chamaedrys.

作者信息

Dias Gilvan O C, Porto Carla, Stüker Caroline Z, Graessler Vanessa, Burrow Robert A, Dalcol Ionara I, da Silva Ubiratan F, Morel Ademir F

机构信息

Departamento de Química, NPPN, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

出版信息

Planta Med. 2007 Mar;73(3):289-92. doi: 10.1055/s-2007-967107. Epub 2007 Mar 12.

DOI:10.1055/s-2007-967107

Abstract

Investigation of the chemical constituents from the roots of Melochia chamaedrys (Sterculiaceae) resulted in the isolation of two quinolinone alkaloids: a new alkaloid, named chamaedrone (1), and a known alkaloid, antidesmone (2). Their structures and stereochemistry were elucidated on the basis of 2D NMR and X-ray crystallographic analysis. Furthermore, alkaloids 1 and 2, and the synthetic analogues 3-6 obtained from 2, were screened for antimicrobial activities.

摘要

对肖槿（梧桐科）根的化学成分进行研究，从中分离出两种喹啉酮生物碱：一种新生物碱，命名为肖槿酮（1），以及一种已知生物碱，樟叶木防己碱（2）。基于二维核磁共振和X射线晶体学分析阐明了它们的结构和立体化学。此外，对生物碱1和2以及从2获得的合成类似物3 - 6进行了抗菌活性筛选。

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