Marioni Gino, Bottin Raffaele, Staffieri Alberto, Altavilla Giuseppe
Department of Otolaryngology-Head and Neck Surgery, University of Padua, Padua, Italy.
Acta Otolaryngol. 2003 Jan;123(1):86-90. doi: 10.1080/0036554021000028070.
Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possible after immunohistochemical investigations of the expression of specific tumour markers but electron microscopic observations help to clarify most of these diagnoses.
具有梭形细胞形态的恶性喉肿瘤相对少见。梭形细胞癌、平滑肌肉瘤、纤维肉瘤、横纹肌肉瘤、恶性黑色素瘤和炎性肌纤维母细胞瘤的鉴别诊断可能特别困难。对特定肿瘤标志物表达进行免疫组化研究后，也可能出现模棱两可和不确定的诊断，但电子显微镜观察有助于明确其中大多数诊断。
