Salehinejad Jahanshah, Pazouki Mahdi, Gerayeli Mohammad Ali
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry and Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Oral Maxillofac Pathol. 2013 May;17(2):306-10. doi: 10.4103/0973-029X.119754.
Inflammatory myofibroblastic tumors (IMTs) are extremely rare neoplasms with a variable natural history and biologic behavior, ranging from completely benign to malignant tumors with fatal outcome. They have no common identifiable cause, although some authors have assumed that any inflammatory stimulus may cause these pseudotumors. They are most commonly found in the lungs. Extrapulmonary sites include abdomen, retroperitoneum and extremities. IMTs rarely affect the head and neck, but the most common subsites in this region include the orbit, larynx, mouth, tonsils, parapharyngeal space, thyroid, parotid and lacrimal glands. There are few reports of inflammatory pseudotumors in the paranasal sinuses. In the maxillary sinus, the initial presenting sign is usually a nonspecific sinonasal mass, which has been growing over a period of weeks or months. On rare occasions, IMT may exhibit malignant transformation. Herein we present a rare case of pathologically proved IMT with malignant transformation which originated in the maxillary sinus of a 29-year-old male.
炎性肌纤维母细胞瘤（IMTs）是极其罕见的肿瘤，其自然病史和生物学行为各异，从完全良性到具有致命结局的恶性肿瘤不等。它们没有共同的可识别病因，尽管一些作者认为任何炎症刺激都可能导致这些假瘤。它们最常见于肺部。肺外部位包括腹部、腹膜后和四肢。IMTs很少累及头颈部，但该区域最常见的亚部位包括眼眶、喉、口腔、扁桃体、咽旁间隙、甲状腺、腮腺和泪腺。关于鼻旁窦炎性假瘤的报道很少。在上颌窦，最初出现的症状通常是鼻窦的非特异性肿块，在数周或数月内逐渐增大。极少数情况下，IMT可能会发生恶性转化。在此，我们报告一例罕见的经病理证实的发生恶性转化的IMT病例，该病例起源于一名29岁男性的上颌窦。
