人单核细胞的麻疹感染。I. 外周血淋巴细胞和单核细胞的急性感染。
Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes.
作者信息
Sullivan J L, Barry D W, Lucas S J, Albrecht P
出版信息
J Exp Med. 1975 Sep 1;142(3):773-84. doi: 10.1084/jem.142.3.773.
A study of the susceptibility of human peripheral blood mononuclear cells to measles virus infection and replication is reported. Resting lymphocytes obtained from adults showed very low levels of infection and virus replication while lymphocytes activated by plant mitogens or allogenic lymphocytes supported mononuclear cells obtained from the umbilical cord of healthy neonates were more susceptible to measles virus infection than those of adults; however, activated cord lymphocytes supported viral replication in the range observed with adult activated lymphocytes. Monocytes obtained from adults were relatively resistant to measles virus infection and replication while neonatal cord blood monocytes supported viral replication to the degree observed with activated lymphocytes. It is hypothesized that infection of acitivated lymphocytes may explain the depression of cell-mediated immunity seen during acute measles virus infection. The significance of the finding that neonatal monocytes are more susceptible to viral infection and replication than adult monocytes is discussed.
本文报道了一项关于人类外周血单个核细胞对麻疹病毒感染和复制易感性的研究。从成年人获取的静息淋巴细胞显示出极低水平的感染和病毒复制，而经植物有丝分裂原或同种异体淋巴细胞激活的淋巴细胞支持病毒复制。从健康新生儿脐带获取的单个核细胞比成年人的更易感染麻疹病毒；然而，激活的脐带淋巴细胞支持病毒复制的程度与成年激活淋巴细胞所观察到的范围相当。从成年人获取的单核细胞对麻疹病毒感染和复制相对有抗性，而新生儿脐带血单核细胞支持病毒复制的程度与激活淋巴细胞所观察到的相当。据推测，激活淋巴细胞的感染可能解释了急性麻疹病毒感染期间所见到的细胞介导免疫的抑制。本文讨论了新生儿单核细胞比成人单核细胞更易受病毒感染和复制这一发现的意义。
Zotero 插件