麻疹病毒在人淋巴细胞中的复制。
Replication of measles virus in human lymphocytes.
作者信息
Hyypiä T, Korkiamäki P, Vainionpää R
出版信息
J Exp Med. 1985 Jun 1;161(6):1261-71. doi: 10.1084/jem.161.6.1261.
Abstract
Replication of measles virus was restricted in human peripheral blood mononuclear cells (PBMC). However, in in vitro-infected, unstimulated cells, active synthesis of viral RNA and proteins occurred, while the release of infectious virus could not be detected. Stimulation with PHA caused a productive infection cycle comparable to the lytic infection. Replication of viral RNA was demonstrated in both T and B cells, and in both OKT4+- and OKT8+-depleted T cell subsets. The presence of measles virus RNA was detected in PBMC isolated from measles patients, and the production of the immunoreactive hemagglutinin protein was defective in these cells.
摘要
麻疹病毒在人外周血单个核细胞（PBMC）中的复制受到限制。然而，在体外感染的未刺激细胞中，病毒RNA和蛋白质会进行活跃合成，但无法检测到传染性病毒的释放。用PHA刺激会引发一个类似于裂解感染的有效感染周期。在T细胞和B细胞以及OKT4⁺和OKT8⁺耗尽的T细胞亚群中均证实了病毒RNA的复制。在从麻疹患者分离的PBMC中检测到了麻疹病毒RNA的存在，并且这些细胞中免疫反应性血凝素蛋白的产生存在缺陷。
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