Epidemiology and ecology of TBE relevant to the production of effective vaccines.

This review focuses on the epidemiology and ecology of the tick-borne encephalitis (TBE) virus including all the factors influencing the ecology of the TBE virus, environmental and climatic conditions, the vectors and reservoir hosts and their interactions. Consequently, the structure and the conditions of natural foci of TBE are described, as well. Special emphasis is given on data regarding the virus prevalence in ticks in the field. In the second part of this review all the epidemiological and surveillance data of TBE in the 27 European countries and in the Far East with risk areas of TBE and in China and Japan are summarised. Therefore the review is a basis for travellers and inhabitants to get background information for their personal risk assessment.