Polidori M Cristina, Mecocci Patrizia
Institute of Physiological Chemistry I, Heinrich-Heine University, Düsseldorf, Germany.
J Alzheimers Dis. 2002 Dec;4(6):517-22. doi: 10.3233/jad-2002-4608.
Oxidative stress is believed to play a major role in the pathogenesis of Alzheimer disease (AD). Plasma concentrations of vitamins C, A and E, of uric acid, thiols and carotenoids were lower and of malondialdehyde (MDA) higher in 35 AD patients (85.9 +/- 5.5 y) compared to 40 controls 85.5 +/- 4.4 y). Differences were significant for vitamin C, vitamin E, lutein, lycopene, alpha-carotene and MDA (p < 0.001). Plasma exposed to peroxyl radicals showed a rate of antioxidant consumption and of MDA production higher in AD patients than in controls. AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure.
氧化应激被认为在阿尔茨海默病（AD）的发病机制中起主要作用。与40名年龄为85.5±4.4岁的对照组相比，35名年龄为85.9±5.5岁的AD患者血浆中维生素C、维生素A、维生素E、尿酸、硫醇和类胡萝卜素的浓度较低，而丙二醛（MDA）的浓度较高。维生素C、维生素E、叶黄素、番茄红素、α-胡萝卜素和MDA的差异具有统计学意义（p<0.001）。暴露于过氧自由基的血浆显示，AD患者的抗氧化剂消耗率和MDA产生率高于对照组。高龄AD患者伴有血浆抗氧化状态不佳、血浆脂质过氧化增加以及对过氧自由基暴露的抵抗力较低。
