Huang Shan, Wang Jun, Fan Dong-Yu, Luo Tong, Li Yanli, Tu Yun-Feng, Shen Ying-Ying, Zeng Gui-Hua, Chen Dong-Wan, Wang Ye-Ran, Chen Li-Yong, Wang Yan-Jiang, Guo Junhong
Department of Neurology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
First Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Front Aging Neurosci. 2022 Jul 18;14:943380. doi: 10.3389/fnagi.2022.943380. eCollection 2022.
Cognitive impairment (CI) has become a worldwide health problem. The relationship between CI and uric acid (UA) is contradictory.
We included participants with a full spectrum of CI, from cognitively unimpaired (CU) to dementia, from the Chongqing Ageing & Dementia Study (CADS).
First, we identified the relationships between serum UA (sUA) and cognitive function in different stages of CI. Second, we analyzed these relationships among different stages and types of CI. Finally, we explored the association between sUA and amyloid/tangle/neurodegeneration (ATN) biomarkers.
We recruited 427 participants from the CADS, including 382 participants with mini-mental state examination (MMSE) evaluation. The levels of sUA were positively correlated with MMSE scores ( < 0.001), and the correlation was prominent in the course of dementia and in the type of Alzheimer's disease (AD). The levels of UA had a positive correlation with plasma amyloid-β 42 (Aβ42) ( = 0.004). Higher levels of sUA weakened the correlation of MMSE scores with CSF ATN biomarkers and the correlation of CSF Aβ42 with tau.
UA is positively correlated with cognitive function, especially in the advanced stage of AD. The probable neuroprotective effects of sUA mainly act on Aβ42 and the downstream pathological cascade.
认知障碍（CI）已成为一个全球性的健康问题。CI与尿酸（UA）之间的关系存在矛盾。
我们纳入了来自重庆衰老与痴呆研究（CADS）的从认知未受损（CU）到痴呆的全谱CI参与者。
首先，我们确定了血清尿酸（sUA）与CI不同阶段认知功能之间的关系。其次，我们分析了不同阶段和类型CI之间的这些关系。最后，我们探讨了sUA与淀粉样蛋白/缠结/神经退行性变（ATN）生物标志物之间的关联。
我们从CADS招募了427名参与者，其中包括382名接受简易精神状态检查（MMSE）评估的参与者。sUA水平与MMSE评分呈正相关（<0.001），且这种相关性在痴呆病程和阿尔茨海默病（AD）类型中尤为突出。UA水平与血浆淀粉样蛋白-β42（Aβ42）呈正相关（=0.004）。较高的sUA水平削弱了MMSE评分与脑脊液ATN生物标志物之间的相关性以及脑脊液Aβ42与tau之间的相关性。
UA与认知功能呈正相关，尤其是在AD晚期。sUA可能的神经保护作用主要作用于Aβ42及其下游病理级联反应。
