Savoie Marc, Kim Sandy S, Soloway Mark S
Department of Urology, University of Miami School of Medicine, Florida, USA.
J Urol. 2003 Apr;169(4):1462-4. doi: 10.1097/01.ju.0000053720.93303.33.
Some patients report that the penis is smaller after radical retropubic prostatectomy for prostate cancer. We performed a prospective study which measured penile length before and after radical retropubic prostatectomy.
A total of 124 men consented to penile measurements before radical prostatectomy performed by the same surgeon. Repeat measurements were performed at 3-month intervals following surgery. Penile measurements (cm.) consisted of flaccid length, stretched length, depth of prepubic fat pad and circumference. Statistical analysis of penile measurements was performed using the paired samples and independent Student's t test, Pearson's correlation and analysis of variance.
Mean patient age was 59.1 (range 42 to 76). No patient had a penile abnormality, for example Peyronie's disease, or history of penile or urethral surgery. The size of the penis was significantly smaller after prostatectomy, and there was a significant difference for flaccid (p <0.001), stretched (p <0.001), prepubic fat pad (p = 0.02) and circumference measurements (p <0.01). Twelve patients (19%) had a 15% or greater decrease in stretched penile length. When dichotomizing groups at the cut point of 15% decrease, the independent t test of prostate size was not significant (t[df 36.7] = -1.83, p = 0.076). Nerve sparing was not significant in relation to change in penile stretched length, (F[df 2, 62] = 0.501, p = 0.609).
Our findings support observations of decreased penile length after radical prostatectomy. Men should be counseled before radical prostatectomy that penile shortening may occur.
一些患者报告称,前列腺癌耻骨后根治性前列腺切除术后阴茎变小。我们进行了一项前瞻性研究,测量耻骨后根治性前列腺切除术前和术后的阴茎长度。
共有124名男性同意在同一位外科医生进行根治性前列腺切除术之前测量阴茎。术后每隔3个月进行重复测量。阴茎测量(厘米)包括疲软长度、拉伸长度、耻骨前脂肪垫深度和周长。使用配对样本和独立样本t检验、Pearson相关性分析和方差分析对阴茎测量数据进行统计分析。
患者平均年龄为59.1岁(范围42至76岁)。没有患者存在阴茎异常,例如佩罗尼氏病,也没有阴茎或尿道手术史。前列腺切除术后阴茎尺寸明显变小,疲软(p<0.001)、拉伸(p<0.001)、耻骨前脂肪垫(p = 0.02)和周长测量(p<0.01)均存在显著差异。12名患者(19%)的阴茎拉伸长度减少了15%或更多。当以15%的降幅作为分界点对分组进行二分法分析时,前列腺大小的独立t检验不显著(t[自由度36.7]= -1.83,p = 0.076)。保留神经与阴茎拉伸长度变化无关(F[自由度2, 62]= 0.501,p = 0.609)。
我们的研究结果支持了根治性前列腺切除术后阴茎长度会减小的观察结果。在进行根治性前列腺切除术之前,应告知男性患者可能会出现阴茎缩短的情况。