Taylor A T, Alazraki N, Henry J E
J Nucl Med. 1976 Jun;17(6):470-2.
In scanning patients for Meckel's diverticulum, the colon occasionally visualizes more rapidly than would be expected simply from gastric secretion and intestinal transit. To gain a better understanding of the intestinal physiology of pertechnetate and thereby to make a more intelligent interpretation of abdominal scans, segments of the gastrointestinal tract of Sprague-Dawley rats were isolated by transection between double ligations. After abdominal closure, the animals received an intravenous injection of 99mTcO4 and were killed at 30, 45, or 150 min after injection. Technetium concentrations in the stomach, colon, and appendiceal contents increased significantly with time after dosing, and after 30 min technetium could be clearly imaged in the stomach, upper small intestine, appendix, and colon. These results suggest that technetium is actively secreted by the intestinal mucosa. Additionally, the results indicate caution in the interpretation of scans in patients with suspected Meckel's diverticulum since, in the rat and probably in the human, significant amounts of technetium can accumulate in the gut apart from gastric secretion and intestinal transit.
在对患者进行梅克尔憩室扫描时，结肠有时显影速度比仅根据胃分泌和肠道转运所预期的要快。为了更好地理解高锝酸盐在肠道的生理过程，从而对腹部扫描做出更明智的解读，通过在双结扎之间横断，分离出斯普拉格-道利大鼠胃肠道的各段。缝合腹部后，给动物静脉注射99mTcO4，并在注射后30、45或150分钟处死。给药后，胃、结肠和阑尾内容物中的锝浓度随时间显著增加，给药30分钟后，胃、小肠上段、阑尾和结肠中的锝能够清晰成像。这些结果表明锝是由肠黏膜主动分泌的。此外，这些结果提示，在解读疑似梅克尔憩室患者的扫描结果时应谨慎，因为在大鼠以及可能在人类中，除了胃分泌和肠道转运外，大量的锝会在肠道中蓄积。
