Yeker D, Büyükünal C, Benli M, Büyükünal E, Urgancioğlu I
Eur J Nucl Med. 1984;9(7):316-9. doi: 10.1007/BF00276461.
The aim of this study was to investigate the effects of prior administration of cimetidine in radionuclide imaging of Meckel's diverticulum. In three groups of seven rats with artificial Meckel's diverticulum, containing ectopic gastric mucosa, the effects of pentagastrin + glucagon plus 99mTc-pertechnetate, as well as cimetidine premedication plus 99mTc-pertechnetate, and 99mTc-pertechnetate alone were compared to attain improved radionuclide imaging of Meckel's diverticulum. This experimental model suggests that the use of cimetidine seemed to have some advantages: (a) nontarget (intestinal) radioactivity was diminished by cimetidine, (b) the target to nontarget (Meckel's diverticulum to intestinal activity) ratio increased with cimetidine pretreatment. This resulted in an enhanced accumulation of pertechnetate in the ectopic gastric mucosa, and reduced excretion of the radionuclide into the lumen. Consequently, better scintiphotograms and a low rate of false results added to the validity of this method.
本研究的目的是探讨西咪替丁预先给药在梅克尔憩室放射性核素成像中的作用。在三组各有七只患有含异位胃黏膜的人工梅克尔憩室的大鼠中，比较了五肽胃泌素+胰高血糖素加99m锝-高锝酸盐、西咪替丁预处理加99m锝-高锝酸盐以及单独使用99m锝-高锝酸盐的效果，以实现梅克尔憩室放射性核素成像的改善。该实验模型表明，使用西咪替丁似乎具有一些优势：(a) 西咪替丁可减少非靶（肠道）放射性；(b) 西咪替丁预处理后靶与非靶（梅克尔憩室与肠道活性）的比率增加。这导致高锝酸盐在异位胃黏膜中的蓄积增强，且放射性核素向肠腔内的排泄减少。因此，更好的闪烁照片和较低的假结果率增加了该方法的有效性。
