Petrokubi R J, Baum S, Rohrer G V
Clin Nucl Med. 1978 Oct;3(10):385-8. doi: 10.1097/00003072-197810000-00004.
Administration of cimetidine prior to pertechnetate imaging in two patients with Meckel's diverticulum resulted in demonstrating the abnormality with unusual clarity. This is presumed due to the cimetidine-mediated retention of pertechnetate in the gastric mucosa. Pertechnetate imaging in two normal subjects with and without cimetidine administration disclosed a marked difference in retention of the radionuclide in the gastric mucosa and its subsequent transit into the intestinal tract. Pertechnetate imaging in conjunction with cimetidine administration appears to result in markedly improved identification of Meckel's diverticulum.
在两名患有梅克尔憩室的患者中，在高锝酸盐成像前给予西咪替丁，结果异常显示得异常清晰。据推测，这是由于西咪替丁介导高锝酸盐在胃黏膜中的潴留。对两名正常受试者在给予和未给予西咪替丁的情况下进行高锝酸盐成像，结果显示胃黏膜中放射性核素的潴留及其随后向肠道的转运存在显著差异。结合西咪替丁给药进行高锝酸盐成像似乎能显著提高梅克尔憩室的识别率。
