Ramaesh T, Mendis B R, Ratnatunga N, Thattil R O
Department of Basic Sciences, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
J Oral Pathol Med. 1998 Feb;27(2):83-6. doi: 10.1111/j.1600-0714.1998.tb02099.x.
Cell and nuclear diameters (CD and ND) were measured in squames obtained from normal buccal mucosa and lesions of oral leukoplakia and squamous carcinoma (SCC) also from buccal mucosa. The study groups consisted of Group 1: normal buccal mucosa (n = 40); Group 2: lesions with no epithelial dysplasia (n = 58); Group 3: lesions with epithelial dysplasia (n = 27); and Group 4: SCC lesions (n = 51). The mean CD and ND values were: Group 1: 51.78 (+/- 0.11) and 8.36 (+/- 0.49); Group 2: 45.73 (+/- 0.16) and 8.31 (+/- 0.68); Group 3: 41.32 (+/- 0.13) and 9.04 (+/- 0.46); Group 4: 38.58 (+/- 0.11) and 10.10 (+/- 0.56) microns, respectively. Correlation between the ND and CD was positive for Group 1 (r = 0.78, P < 0.05) and Group 2 (r = 0.33, P < 0.05). There were no significant correlations in Groups 3 and 4. ANOVA showed significant differences (P < 0.05) for CD between all four groups. Except between Groups 1 and 2, the ND was significantly different (P < 0.05) between all groups. The results indicate that ND and CD could possibly be sensitive parameters in the diagnosis of oral premalignant and malignant lesions.
在取自正常颊黏膜以及同样取自颊黏膜的口腔白斑和鳞状细胞癌（SCC）病变的鳞屑中测量细胞直径和核直径（CD和ND）。研究组包括：第1组：正常颊黏膜（n = 40）；第2组：无上皮发育异常的病变（n = 58）；第3组：有上皮发育异常的病变（n = 27）；以及第4组：SCC病变（n = 51）。平均CD和ND值分别为：第1组：51.78（±0.11）和8.36（±0.49）；第2组：45.73（±0.16）和8.31（±0.68）；第3组：41.32（±0.13）和9.04（±0.46）；第4组：38.58（±0.11）和10.10（±0.56）微米。第1组（r = 0.78，P < 0.05）和第2组（r = 0.33，P < 0.05）中ND与CD之间呈正相关。第3组和第4组中不存在显著相关性。方差分析显示所有四组之间的CD存在显著差异（P < 0.05）。除第1组和第2组之间外，所有组之间的ND均存在显著差异（P < 0.05）。结果表明，ND和CD可能是诊断口腔癌前病变和恶性病变的敏感参数。
