Bell S C, Wei P H
J Med Chem. 1976 Apr;19(4):524-30. doi: 10.1021/jm00226a016.
A number of tricyclic and bicyclic fused thiazole-2-acetic acid derivatives were prepared and the chemistry and biological properties of these compounds are discussed. Many of the esters exhibited antitubercular activity. The bicyclic thiazole-2-acetic acids had antidepressant activity. Interesting antimetastatic activity against Lewis lung tumor in mice was found with several compounds, in particular, the thiazolo[3,2-a]benzimidazole-2-acetic acid derivative XI.
制备了多种三环和双环稠合噻唑-2-乙酸衍生物，并对这些化合物的化学性质和生物学性质进行了讨论。许多酯类表现出抗结核活性。双环噻唑-2-乙酸具有抗抑郁活性。几种化合物对小鼠Lewis肺癌具有有趣的抗转移活性，特别是噻唑并[3,2-a]苯并咪唑-2-乙酸衍生物XI。
