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1
Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity.通过自然内源性逆转录去除亲环素A的1型人类免疫缺陷病毒颗粒的治疗可恢复其感染性。
J Virol. 2003 Apr;77(7):4431-4. doi: 10.1128/jvi.77.7.4431-4434.2003.
2
Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity.Nef与亲环素A增强1型人类免疫缺陷病毒感染性的机制独立性
Virology. 1998 Aug 15;248(1):139-47. doi: 10.1006/viro.1998.9254.
3
Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.含有HIV-2或猴免疫缺陷病毒Nef的嵌合型1型人类免疫缺陷病毒（HIV-1）病毒粒子对环孢素治疗具有抗性。
J Virol. 2004 Feb;78(4):1843-50. doi: 10.1128/jvi.78.4.1843-1850.2004.
4
Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.通过病毒内逆转录使缺乏nef的1型人类免疫缺陷病毒毒株恢复野生型感染性。
J Virol. 2001 Dec;75(24):12081-7. doi: 10.1128/JVI.75.24.12081-12087.2001.
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Nef enhances HIV-1 infectivity via association with the virus assembly complex.Nef通过与病毒组装复合体结合来增强HIV-1的感染性。
Virology. 2008 Apr 10;373(2):287-97. doi: 10.1016/j.virol.2007.12.001. Epub 2008 Jan 14.
6
Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity.靶细胞亲环素A调节1型人类免疫缺陷病毒的感染性。
J Virol. 2004 Dec;78(23):12800-8. doi: 10.1128/JVI.78.23.12800-12808.2004.
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Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.用水泡性口炎病毒糖蛋白对1型人类免疫缺陷病毒（HIV-1）进行假型化，可使HIV-1进入内吞途径，并抑制对Nef的需求和对环孢素A的敏感性。
J Virol. 1997 Aug;71(8):5871-7. doi: 10.1128/JVI.71.8.5871-5877.1997.
8
Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.亲环蛋白与进入的1型人类免疫缺陷病毒衣壳相互作用，对人类细胞中的感染性产生相反影响。
J Virol. 2005 Jan;79(1):176-83. doi: 10.1128/JVI.79.1.176-183.2005.
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Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type.通过Gag序列和靶细胞类型对HIV-1感染性及亲环素A依赖性的调节
Retrovirology. 2009 Mar 2;6:21. doi: 10.1186/1742-4690-6-21.
10
Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.含有猴免疫缺陷病毒nef基因的嵌合型人类免疫缺陷病毒1型病毒粒子对环孢菌素A具有抗性。
J Virol. 2005 Mar;79(5):3211-6. doi: 10.1128/JVI.79.5.3211-3216.2005.

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Reverse transcription complex: the key player of the early phase of HIV replication.逆转录复合物：HIV复制早期的关键参与者。
Future Virol. 2007 Jan 1;2(1):49-64. doi: 10.2217/17460794.2.1.49.
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The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability.HIV-1 衣壳蛋白的结构域间连接区是核心组装和稳定性的关键决定因素。
Virology. 2011 Dec 20;421(2):253-65. doi: 10.1016/j.virol.2011.09.012. Epub 2011 Oct 26.
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Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.含有猴免疫缺陷病毒nef基因的嵌合型人类免疫缺陷病毒1型病毒粒子对环孢菌素A具有抗性。
J Virol. 2005 Mar;79(5):3211-6. doi: 10.1128/JVI.79.5.3211-3216.2005.
4
Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.亲环蛋白与进入的1型人类免疫缺陷病毒衣壳相互作用，对人类细胞中的感染性产生相反影响。
J Virol. 2005 Jan;79(1):176-83. doi: 10.1128/JVI.79.1.176-183.2005.
5
Characterization of Nef-CXCR4 interactions important for apoptosis induction.对诱导细胞凋亡至关重要的Nef-CXCR4相互作用的表征。
J Virol. 2004 Oct;78(20):11084-96. doi: 10.1128/JVI.78.20.11084-11096.2004.
6
Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.含有HIV-2或猴免疫缺陷病毒Nef的嵌合型1型人类免疫缺陷病毒（HIV-1）病毒粒子对环孢素治疗具有抗性。
J Virol. 2004 Feb;78(4):1843-50. doi: 10.1128/jvi.78.4.1843-1850.2004.
7
Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase.1型人类免疫缺陷病毒N端衣壳突变体，其核心含有衣壳蛋白水平异常高且几乎没有逆转录酶。
J Virol. 2003 Dec;77(23):12592-602. doi: 10.1128/jvi.77.23.12592-12602.2003.

本文引用的文献

1
Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation.如旋转接种所揭示的，亲环蛋白a在1型人类免疫缺陷病毒进入及进入后事件中发挥着不同作用。
J Virol. 2002 May;76(9):4671-7. doi: 10.1128/jvi.76.9.4671-4677.2002.
2
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.人亲环素A催化天然HIV-1衣壳中的顺/反异构化反应。
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5247-52. doi: 10.1073/pnas.082100499. Epub 2002 Apr 2.
3
trans-Complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity.亲环素A缺陷型病毒的反式互补拯救表明，1型人类免疫缺陷病毒复制过程中对亲环素A的需求与其异构酶活性无关。
J Virol. 2002 Mar;76(5):2255-62. doi: 10.1128/jvi.76.5.2255-2262.2002.
4
Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.通过病毒内逆转录使缺乏nef的1型人类免疫缺陷病毒毒株恢复野生型感染性。
J Virol. 2001 Dec;75(24):12081-7. doi: 10.1128/JVI.75.24.12081-12087.2001.
5
Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIV(MAC) gag capsid region.携带一小部分猴免疫缺陷病毒SIV（MAC）gag衣壳区域的1型人类免疫缺陷病毒分离株的亲环素A非依赖性复制。
J Virol. 2001 Nov;75(21):10527-31. doi: 10.1128/JVI.75.21.10527-10531.2001.
6
CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.CD147通过与病毒相关的亲环素A相互作用促进HIV-1感染。
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6360-5. doi: 10.1073/pnas.111583198. Epub 2001 May 15.
7
Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells.亲环素A调节HIV-1感染性，这在人类T细胞的基因靶向研究中得到了证实。
EMBO J. 2001 Mar 15;20(6):1300-9. doi: 10.1093/emboj/20.6.1300.
8
Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core.人类免疫缺陷病毒1型病毒粒子因病毒体内逆转录继发的形态学变化：有证据表明逆转录可能并非在完整的病毒核心内发生。
J Hum Virol. 2000 May-Jun;3(3):165-72.
9
Association of Nef with the human immunodeficiency virus type 1 core.Nef与1型人类免疫缺陷病毒核心的关联。
J Virol. 1999 Oct;73(10):8824-30. doi: 10.1128/JVI.73.10.8824-8830.1999.
10
Cyclophilin A incorporation is not required for human immunodeficiency virus type 1 particle maturation and does not destabilize the mature capsid.亲环素A的掺入对于1型人类免疫缺陷病毒颗粒的成熟并非必需，并且不会使成熟衣壳不稳定。
Virology. 1999 Apr 25;257(1):261-74. doi: 10.1006/viro.1999.9669.

通过自然内源性逆转录去除亲环素A的1型人类免疫缺陷病毒颗粒的治疗可恢复其感染性。

Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity.

作者信息

Khan Mahfuz, Garcia-Barrio Minerva, Powell Michael D

机构信息

Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA.

出版信息

J Virol. 2003 Apr;77(7):4431-4. doi: 10.1128/jvi.77.7.4431-4434.2003.

DOI:10.1128/jvi.77.7.4431-4434.2003
PMID:12634401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC150660/
Abstract

We have previously shown that virions with nef deleted can be restored to wild-type infectivity by treatment to induce natural endogenous reverse transcription (NERT). Since Nef and cyclophilin A (CyPA) appear to act in similar ways on postentry events, we determined whether NERT treatment would restore infectivity to virions depleted of CyPA. Our results show that the infectivity of virions depleted of CyPA by treatment with cyclosporine A could be restored by NERT treatment, while mutants in the CyPA binding loop of capsid could only be partially restored. These results suggest that CyPA is involved in some aspect of the uncoating process.

摘要

我们之前已经表明，通过诱导自然内源性逆转录（NERT）的处理，缺失nef的病毒粒子可以恢复到野生型感染性。由于Nef和亲环素A（CyPA）似乎在进入后事件中以相似的方式起作用，我们确定NERT处理是否会恢复缺失CyPA的病毒粒子的感染性。我们的结果表明，用环孢素A处理使CyPA缺失的病毒粒子的感染性可以通过NERT处理恢复，而衣壳的CyPA结合环中的突变体只能部分恢复。这些结果表明，CyPA参与了解衣过程的某些方面。