颅内压对严重颅脑损伤诱发的呼吸暂停和儿茶酚胺激增的反应。
Intracranial pressure response to severe head injury induced apnea and catecholamine surge.
作者信息
Anderson Robert E, Atkinson John L D
机构信息
Department of Neurological Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
出版信息
J Trauma. 2003 Mar;54(3):550-4. doi: 10.1097/01.TA.0000047049.64695.69.
BACKGROUND
Apnea and catecholamine surge have been known sequelae in the first few minutes of postexperimentally induced severe head injury for over a century. However, the intracranial pressure (ICP) response to these two pathophysiologic processes is poorly understood.
METHODS
We used the rat fluid percussion head injury model to study apnea and catecholamine surge separately and in combination on measured ICP response
RESULTS
The three experimental groups of apnea, hypertensive surge, and both combined revealed significantly different ICP responses with markedly elevated pressures correlating closely with mean arterial blood pressure.
CONCLUSION
ICP and mean arterial blood pressure correlate closely in the first few minutes after head injury in the absence of space-occupying hematomas, and may initiate pathophysiologic sequelae that can only be treated by earlier medical intervention at the scene.
背景
一个多世纪以来，实验性诱导的严重头部损伤后的最初几分钟内，呼吸暂停和儿茶酚胺激增一直是已知的后遗症。然而，人们对颅内压（ICP）对这两种病理生理过程的反应了解甚少。
方法
我们使用大鼠液压冲击性头部损伤模型，分别单独以及联合研究呼吸暂停和儿茶酚胺激增对测量的颅内压反应的影响。
结果
呼吸暂停、高血压激增以及两者联合的三个实验组显示出明显不同的颅内压反应，压力显著升高与平均动脉血压密切相关。
结论
在没有占位性血肿的情况下，头部损伤后的最初几分钟内，颅内压与平均动脉血压密切相关，并且可能引发只能通过现场早期医疗干预来治疗的病理生理后遗症。
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