Hörbrand F, Schrank C, Henckel-Donnersmarck G, Mühlbauer W
Abteilung für Plastische- und Handchirurgie/Zentrum für Schwerbrandverletzte, Krankenhaus München-Bogenhausen.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2003 Mar;38(3):151-7. doi: 10.1055/s-2003-37773.
There is no doubt that underlying medical problems such as concomitant diseases or risk factors play a role in increasing patient morbidity and mortality. These factors are already integrated in trauma scores but preexisting diseases have no impact on burn scores yet. This study was performed to examine the predictive value of the classical burn variables that are integrated in the Abbreviated Burn Severity Index (ABSI). The preexisting diseases and risk factors in burn patients within our burn center were evaluated, with the aim of incorporating these evaluations into a new burn score. This modified burn score was used to optimize the predictive value of burn mortality.
This study included 443 intensive care burn patients. Demographic, injury, age, total body surface area burned (TBSAB), full thickness burn (FTB), inhalation injury (IHT), sex, medical comorbidities, intensive care and outcome data were documented. Univariate analyses, stepwise logistic regression and the Receiver Operating Curve were used to generate values for the probability of death.
Univariate analyses identified the following risk factors for their relationship with mortality: TBSAB, age, IHT, FTB, sex and medical comorbidities (cardiovascular, pulmonary, renal and endocrinological). Logistic Regression showed that total body surface area burned and age correlated most significantly with the probability of poor outcome. There were weaker correlations between IHT and FTB. No main effect was registered for gender and preexisting medical problems. The greatest area under the ROC curve was registered for our modified ABSI when comorbidities and risk factors were integrated.
The results of this study show that the Abbreviated Burn Severity Index is an appropriate burn score for estimating the risk of mortality after burn trauma. However, in addition to the classical variables, preexisting diseases and risk factors have a significant influence on the outcome and therefore should be incorporated into a new burn score to predict mortality more accurately.
毫无疑问,诸如伴发疾病或风险因素等潜在医学问题在增加患者发病率和死亡率方面发挥着作用。这些因素已被纳入创伤评分,但既往疾病对烧伤评分尚无影响。本研究旨在检验纳入简明烧伤严重程度指数(ABSI)的经典烧伤变量的预测价值。对我们烧伤中心烧伤患者的既往疾病和风险因素进行评估,目的是将这些评估纳入新的烧伤评分。这个改良的烧伤评分用于优化烧伤死亡率的预测价值。
本研究纳入了443例重症监护烧伤患者。记录了人口统计学、损伤情况、年龄、烧伤总面积(TBSAB)、全层烧伤(FTB)、吸入性损伤(IHT)、性别、内科合并症、重症监护情况及转归数据。采用单因素分析、逐步逻辑回归和受试者工作特征曲线来生成死亡概率值。
单因素分析确定了以下与死亡率相关的风险因素:烧伤总面积、年龄、吸入性损伤、全层烧伤、性别和内科合并症(心血管、肺、肾和内分泌方面)。逻辑回归显示烧伤总面积和年龄与不良转归概率的相关性最为显著。吸入性损伤和全层烧伤之间的相关性较弱。性别和既往疾病未显示出主要影响。当合并症和风险因素被纳入时,我们改良的ABSI在ROC曲线下的面积最大。
本研究结果表明,简明烧伤严重程度指数是评估烧伤创伤后死亡风险的合适烧伤评分。然而,除了经典变量外,既往疾病和风险因素对转归有显著影响因此应纳入新的烧伤评分以更准确地预测死亡率。