Harris A, Migliardi R, Rechtman E, Cole C N, Yee A B, Garzozi H J
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202, USA.
Eur J Ophthalmol. 2003 Jan-Feb;13(1):24-31. doi: 10.1177/112067210301300104.
To compare the effects of latanoprost (Xalatan) and dorzolamide (Trusopt) on ocular hemodynamics in normal-tension glaucoma patients.
A randomized, single-masked, parallel design study was conducted. After a 4-week washout period, 20 normal tension glaucoma patients, recruited from a single university-based ophthalmology clinic, received either latanoprost once daily or dorzolamide 3 times daily for 4 weeks. The subjects were examined at baseline and post-treatment. Outcome measures included heart rate (HR), blood pressure (BP), logMar visual acuity (VA), contrast sensitivity (CS), intraocular pressure (IOP), color Doppler imaging (CDI), and fluorescein angiography with the Rodenstock scanning laser ophthalmoscope (SLO). CDI measurements of the retrobulbar vessels included peak systolic velocity, end diastolic velocity, and the calculated resistance index. Arterio-venous passage time (AVP) in the superior and inferior temporal retina was calculated from the SLO angiograms.
Neither dorzolamide nor latanoprost had any statistically significantly effect on HR or BP. Both drugs significantly lowered IOP without altering calculated ocular perfusion pressure (p<0.05). There was no statistically significant difference in any CDI measurement. Dorzolamide significantly decreased AVP time in the superior retina (p=0.011), while latanoprost did not (p=0.62).
Dorzolamide, unlike latanoprost, significantly reduced AVP times in the superior temporal retina in normal tension glaucoma (NTG) patients.
比较拉坦前列素（适利达）和多佐胺（Trusopt）对正常眼压性青光眼患者眼部血流动力学的影响。
进行了一项随机、单盲、平行设计研究。经过4周的洗脱期后，从一家大学眼科诊所招募的20名正常眼压性青光眼患者，接受每日一次拉坦前列素或每日3次多佐胺治疗，为期4周。在基线和治疗后对受试者进行检查。观察指标包括心率（HR）、血压（BP）、对数最小分辨角视力（VA）、对比敏感度（CS）、眼压（IOP）、彩色多普勒成像（CDI）以及使用罗敦司得扫描激光检眼镜（SLO）进行的荧光素血管造影。球后血管的CDI测量包括收缩期峰值速度、舒张末期速度以及计算得出的阻力指数。从SLO血管造影图计算颞上和颞下视网膜的动静脉通过时间（AVP）。
多佐胺和拉坦前列素对HR或BP均无统计学显著影响。两种药物均显著降低眼压，且未改变计算得出的眼灌注压（p<0.05）。任何CDI测量均无统计学显著差异。多佐胺显著缩短了上视网膜的AVP时间（p=0.011），而拉坦前列素则无此作用（p=0.62）。
与拉坦前列素不同，多佐胺可显著缩短正常眼压性青光眼（NTG）患者颞上视网膜的AVP时间。
