Mizoguchi Takanori, Ozaki Mineo, Unoki Kazuhiko, Dake Yoshinori, Eto Takahiko, Arai Miki
Mizoguchi Eye Clinic.
Clin Ophthalmol. 2012;6:1579-84. doi: 10.2147/OPTH.S33414. Epub 2012 Sep 25.
We compared the intraocular pressure (IOP)-lowering effect of tafluprost 0.0015% once daily with travoprost 0.004% once daily in Japanese patients with normal-tension glaucoma (NTG).
One hundred sixteen patients with NTG were randomized to use tafluprost 0.0015% or travoprost 0.004% once daily for 12 weeks, followed by a washout period of 4 weeks between switching medications. IOP was measured at baseline and 4, 8, and 12 weeks of each treatment period.
Ninety patients completed both treatment periods and had IOP data available for evaluation. In both groups, a significant decrease in IOP was observed for all measurement points compared with baseline values (P < 0.0001). There was no significant difference in IOP at each time point between the two groups. Both drugs were effective (defined as more than 10% IOP reduction) in 39 (43%) of 90 patients; only tafluprost was effective in 26 (29%) patients, and only travoprost was effective in 17 (19%) patients. Eight (9%) patients were nonresponders to both drugs.
Tafluprost and travoprost were equally effective in lowering IOP in patients with normal-tension glaucoma. However, patients with normal-tension glaucoma may vary in response to each medication.
我们比较了0.0015%他氟前列素每日一次与0.004%曲伏前列素每日一次对日本正常眼压性青光眼（NTG）患者的降眼压效果。
116例NTG患者被随机分为两组，分别每日一次使用0.0015%他氟前列素或0.004%曲伏前列素，持续12周，然后在换药期间有4周的洗脱期。在每个治疗期的基线、4周、8周和12周测量眼压。
90例患者完成了两个治疗期并拥有可供评估的眼压数据。在两组中，与基线值相比，所有测量点的眼压均显著降低（P < 0.0001）。两组在每个时间点的眼压均无显著差异。90例患者中有39例（43%）使用两种药物均有效（定义为眼压降低超过10%）；仅他氟前列素有效的患者有26例（29%），仅曲伏前列素有效的患者有17例（19%）。8例（9%）患者对两种药物均无反应。
他氟前列素和曲伏前列素在降低正常眼压性青光眼患者眼压方面同样有效。然而，正常眼压性青光眼患者对每种药物的反应可能有所不同。
