Nagata A, Aono S, Nakatani H
Lipids. 1976 Mar;11(3):167-71. doi: 10.1007/BF02532853.
The effect of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl] linoleamide (PTLA) on lipid levels in serum and liver was compared with that of sitosterols in rats maintained on a diet supplemented with 1% of cholesterol, 0.5% of ox bile extracts, and 10% of hydrogenated coconut oil for 8 weeks. When PTLA was added to the diet at a level of 0.1%, the mean liver cholesterol level of male rats was reduced to 41% of the control and that of female rats was reduced to 19% of the control. In female rats, which showed higher cholesterol levels in serum and liver than male rats after cholesterol feeding, PTLA lowered the liver cholesterol level even at 0.0008% in the diet. Serum cholesterol was lowered by PTLA but not so markedly as liver cholesterol. The inhibition of cholesterol deposition in the liver suggests that the interference with cholesterol absorption is one of the main actions of PTLA. Sitosterols showed a similar pattern of lipid-lowering action, but the potency was far less than that of PTLA.
将（-）N-[α-苯基-β-（对甲苯基）乙基]亚油酸酰胺（PTLA）与甾醇对在补充有1%胆固醇、0.5%牛胆汁提取物和10%氢化椰子油的饮食中饲养8周的大鼠血清和肝脏脂质水平的影响进行了比较。当以0.1%的水平将PTLA添加到饮食中时，雄性大鼠的平均肝脏胆固醇水平降至对照组的41%，雌性大鼠的平均肝脏胆固醇水平降至对照组的19%。在喂食胆固醇后血清和肝脏胆固醇水平高于雄性大鼠的雌性大鼠中，即使饮食中PTLA含量为0.0008%，肝脏胆固醇水平也会降低。PTLA可降低血清胆固醇，但不如降低肝脏胆固醇明显。肝脏中胆固醇沉积的抑制表明，干扰胆固醇吸收是PTLA的主要作用之一。甾醇表现出类似的降脂作用模式，但其效力远低于PTLA。
