Rampin Olivier, Jérôme Nathalie, Suaudeau Charles
Olivier Rampin, Laboratoire de Neurobiologie des Fonctions Végétatives, UR1060, Bat 325, France.
Life Sci. 2003 Apr 11;72(21):2329-36. doi: 10.1016/s0024-3205(03)00122-x.
Dopaminergic pathways play a key role in the central control of sexual behavior. Stimulation of central dopaminergic receptors elicits penile erection in a variety of species and has been proposed as a treatment option for erectile dysfunction in humans. The present study investigated the proerectile effects of apomorphine in mice. In this species, subcutaneous injection of apomorphine (range: 0.11-110 microg/kg sc) elicited three different behavioral responses: erection, erection-like responses and genital grooming. Proerectile effects of apomorphine were dose-dependent. More than 50% of mice displayed erections after administration of 1.1-11 microg/kg of apomorphine sc. Proerectile effects of apomorphine were blocked by haloperidol, a central D2 antagonist, but not by domperidone, a peripherally active dopaminergic antagonist. We conclude that apomorphine elicits erection in mice. This effect is dose-dependent and due to activation of central D2 dopaminergic receptors. The mouse model may be useful for pharmacological approaches designed to provide a better understanding of the central mechanisms of penile erection and sexual behavior.
多巴胺能通路在性行为的中枢控制中起关键作用。刺激中枢多巴胺能受体会在多种物种中引发阴茎勃起，并且已被提议作为治疗人类勃起功能障碍的一种选择。本研究调查了阿扑吗啡对小鼠的促勃起作用。在该物种中，皮下注射阿扑吗啡（范围：0.11 - 110微克/千克皮下注射）引发了三种不同的行为反应：勃起、类似勃起的反应和生殖器梳理行为。阿扑吗啡的促勃起作用呈剂量依赖性。皮下注射1.1 - 11微克/千克阿扑吗啡后，超过50%的小鼠出现勃起。阿扑吗啡的促勃起作用被中枢D2拮抗剂氟哌啶醇阻断，但未被外周活性多巴胺能拮抗剂多潘立酮阻断。我们得出结论，阿扑吗啡可引发小鼠勃起。这种作用是剂量依赖性的，并且是由于中枢D2多巴胺能受体的激活。该小鼠模型可能有助于设计药理学方法，以更好地理解阴茎勃起和性行为的中枢机制。
