Abdelgadir M, Elbagir M, Eltom A, Eltom M, Berne C
Department of Medical Sciences, Uppsala University Hospital, Sweden.
Diabetes Res Clin Pract. 2003 Apr;60(1):41-7. doi: 10.1016/s0168-8227(02)00277-2.
To investigate the influence of obstetric factors and indices of maternal metabolic control on perinatal morbidity and mortality, 88 diabetic pregnant Sudanese women (type 1, n=38; type 2, n=31; gestational diabetes, n=19) and 50 non-diabetic pregnant control women were studied. The mean fasting blood glucose was 11.1+/-2.8 mmol/l and the mean HbA(1c) at booking interview was 8.8+/-2.1% in the diabetic women. Pregnancy complications such as Caesarean sections, urinary tract infections, pregnancy-induced hypertension and intrauterine foetal death were higher among diabetic compared with control women (P<0.0001) and varied with the type of diabetes. Infants of diabetic mothers had a higher incidence of neonatal complications than those of non-diabetic women (54.4% vs. 20.0%; P<0.0001). Infants without complications and who were born to diabetic mothers had better Apgar scores at 5 min (9.8+/-0.5 vs. 8.9+/-1.6; P<0.01) and lower cord C-peptide when compared to infants with complications (P<0.05). In conclusion, the prevalence of maternal and neonatal complications among Sudanese diabetic women and their infants is high. Maternal hyperglycaemia is an important factor affecting maternal wellbeing and neonatal morbidity and mortality.
为了研究产科因素和母体代谢控制指标对围产期发病率和死亡率的影响，对88名患有糖尿病的苏丹孕妇（1型糖尿病，n = 38；2型糖尿病，n = 31；妊娠期糖尿病，n = 19）和50名非糖尿病孕妇进行了研究。糖尿病孕妇的平均空腹血糖为11.1±2.8 mmol/l，在首次产检时的平均糖化血红蛋白（HbA₁c）为8.8±2.1%。与对照组女性相比，糖尿病患者剖宫产、尿路感染、妊娠高血压和宫内胎儿死亡等妊娠并发症更高（P<0.0001），且因糖尿病类型而异。糖尿病母亲的婴儿比非糖尿病母亲的婴儿有更高的新生儿并发症发生率（54.4%对20.0%；P<0.0001）。与有并发症的婴儿相比，无并发症且母亲患有糖尿病的婴儿在出生后5分钟时阿氏评分更好（9.8±0.5对8.9±1.6；P<0.01），脐带C肽水平更低（P<0.05）。总之，苏丹糖尿病女性及其婴儿中母体和新生儿并发症的患病率很高。母体高血糖是影响母体健康以及新生儿发病率和死亡率的一个重要因素。
