Rejdak Robert, Toczołowski Jerzy, Kurkowski Jacek, Kamiński Marek L, Rejdak Konrad, Stelmasiak Zbigniew, Grieb Paweł
2nd Department of Ophthalmology, Medical University, Lublin, Poland.
Med Sci Monit. 2003 Mar;9(3):PI24-8.
Increased latency and reduced amplitude of visual evoked potentials (VEP), frequently encountered in ocular hypertension or open-angle glaucoma, suggest slowed neural conduction in the visual pathways. An improvement in VEP latency and amplitude has been reported following repeated intramuscular injections of citicoline, a neuroprotective drug. Our aim was to find whether citicoline given orally would produce a similar effect.
MATERIAL/METHODS: VEP latency and amplitude were measured in 21 glaucomatous eyes prior to and after two bi-weekly courses of citicoline taken orally in a dose of 1 gram/day. The treatment courses were separated by a two-week break; post-treatment VEP measurement was performed two weeks after the end of the second treatment.
62% of the eyes showed a response to the treatment, with VEP latency reduced from 123.5 (3.9 SEM) ms to 111.9 (1.9 SEM) ms (P=0.0008), and VEP amplitude increased from 6.56 (1.39 SEM) to 7.88 (1.16 SEM) (P=0.04).
Citicoline given orally improves visual evoked potentials in some glaucoma patients.
在高眼压症或开角型青光眼中经常出现的视觉诱发电位（VEP）潜伏期延长和波幅降低，提示视觉通路中的神经传导减慢。据报道，反复肌肉注射神经保护药物胞磷胆碱后，VEP潜伏期和波幅有所改善。我们的目的是探究口服胞磷胆碱是否会产生类似效果。
材料/方法：对21只青光眼患眼在口服剂量为1克/天的胞磷胆碱、每两周一个疗程、共两个疗程之前和之后测量VEP潜伏期和波幅。两个疗程之间间隔两周；在第二个疗程结束后两周进行治疗后VEP测量。
62%的患眼对治疗有反应，VEP潜伏期从123.5（标准误3.9）毫秒降至111.9（标准误1.9）毫秒（P = 0.0008），VEP波幅从6.56（标准误1.39）增至7.88（标准误1.16）（P = 0.04）。
口服胞磷胆碱可改善部分青光眼患者的视觉诱发电位。
