Pahor D
Department of Ophthamology, Teaching Hospital Maribor, Ljubljanska, Slovenia.
Eye (Lond). 2003 Mar;17(2):177-82. doi: 10.1038/sj.eye.6700292.
The aim of the present study was to compare retinal light sensitivity between normal healthy subjects and chronic renal failure patients treated with maintenance haemodialysis (HD), as well as to determine whether there is a correlation between visual field loss and the age of HD patients, duration of HD treatment and hypertensive retinopathy in HD patients.
A total of 50 eyes of 25 HD patients (16 male, nine female) and 30 eyes of 15 controls underwent visual field testing on the C 30-2 program of the Humphrey field analyser.
Significant reduction in retinal light sensitivity with mean deviation (MD) P values less than 5% was found in 36% (18 eyes), pattern standard deviation (PSD) P values less than 5% in 16 eyes (32%) and corrected pattern standard deviation (CPSD) P values less than 5% in 16 eyes (32%) of HD patients. In control group, all MD, PSD, and CPSD P values were within normal limits. No correlation between reduction of retinal light sensitivity and age or duration of dialysis treatment was observed in HD patients. The reduction of retinal light sensitivity was significantly greater in HD patients with hypertensive retinopathy.
In 36% of eyes from our HD patients without ophthalmoscopically evident arteriolar occlusion on fundus examination, a significant reduction in retinal light sensitivity was observed. The reduction was significantly greater in HD patients with hypertensive retinopathy.
本研究旨在比较正常健康受试者与接受维持性血液透析（HD）治疗的慢性肾衰竭患者之间的视网膜光敏感度，并确定HD患者的视野缺损与年龄、HD治疗时长以及高血压性视网膜病变之间是否存在相关性。
对25例HD患者（16例男性，9例女性）的50只眼睛和15例对照者的30只眼睛，使用Humphrey视野分析仪的C 30 - 2程序进行视野测试。
HD患者中，平均偏差（MD）P值小于5%时，视网膜光敏感度显著降低的有36%（18只眼）；模式标准差（PSD）P值小于5%的有16只眼（32%）；校正模式标准差（CPSD）P值小于5%的有16只眼（32%）。对照组中，所有MD、PSD和CPSD P值均在正常范围内。HD患者中未观察到视网膜光敏感度降低与年龄或透析治疗时长之间存在相关性。高血压性视网膜病变的HD患者视网膜光敏感度降低更为显著。
在我们的HD患者中，36%的眼睛在眼底检查中无明显的小动脉闭塞，但视网膜光敏感度仍显著降低。高血压性视网膜病变的HD患者视网膜光敏感度降低更为显著。
