Lewis Michael R, Tracy Russell P
Department of Pathology, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA.
Curr Diab Rep. 2002 Feb;2(1):96-9. doi: 10.1007/s11892-002-0064-8.
The complex relationship between immunity and the insulin resistance syndrome is likely mediated to a significant degree by cytokines and the inflammatory proteins they induce. Epidemiologic work has revealed associations between cytokines and clinically evident insulin resistance, and mechanistic studies have yielded insight into the induction of insulin resistance at the cellular level by cytokines such as tumor necrosis factor-alpha. Genetic polymorphisms significantly influence this relationship, and variations in cellular immunity as manifested by T-helper cell phenotype are likely to be important as well. Further elucidation of the link between immunity and insulin resistance may lead to more effective treatment, and potentially prevention, of the insulin resistance syndrome.
免疫与胰岛素抵抗综合征之间的复杂关系很可能在很大程度上由细胞因子及其诱导的炎症蛋白介导。流行病学研究揭示了细胞因子与临床明显的胰岛素抵抗之间的关联，而机制研究已深入了解诸如肿瘤坏死因子-α等细胞因子在细胞水平上诱导胰岛素抵抗的过程。基因多态性显著影响这种关系，并且以辅助性T细胞表型表现的细胞免疫变化可能也很重要。进一步阐明免疫与胰岛素抵抗之间的联系可能会带来更有效的胰岛素抵抗综合征治疗方法，并有可能实现预防。
