Kramer Daniel, Raji Annaswamy, Plutzky Jorge
Vascular Disease Prevention Program, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Avenue, EBRC 323, Boston, MA 02115, USA.
Curr Diab Rep. 2003 Feb;3(1):11-8. doi: 10.1007/s11892-003-0047-4.
Type 2 diabetes mellitus is a chronic insidious process contributing to an overwhelming amount of morbidity and mortality, much of which is related to atherosclerosis, which often accompanies and complicates the natural history of diabetes. Although considerable attention has focused on new insights into diabetic mechanisms and emerging treatments, perhaps one of the greatest opportunities for decreasing the toll of diabetes and its late-stage complications may be intervening earlier in the disease process. Such notions redirect attention toward the concept of prediabetes mellitus as a potentially discrete syndrome, which may be identifiable in clinical practice. This article seeks to offer support for this hypothesis by considering the data surrounding prediabetes mellitus, with particular attention on the mechanistic and clinical links to atherosclerosis.
2型糖尿病是一个慢性隐匿性过程，会导致大量发病和死亡，其中许多与动脉粥样硬化有关，而动脉粥样硬化常伴随糖尿病自然病程并使其复杂化。尽管相当多的注意力集中在对糖尿病机制的新见解和新兴治疗方法上，但降低糖尿病及其晚期并发症危害的最大机会之一可能是在疾病过程中更早地进行干预。这些观点将注意力重新转向了糖尿病前期这一潜在的独立综合征概念，它在临床实践中可能是可识别的。本文旨在通过考虑围绕糖尿病前期的数据来支持这一假设，特别关注与动脉粥样硬化的机制和临床联系。
