Schulin-Zeuthen Carolina, Yamamoto Masami, Pires Yumay, Mayerson David, Cattani Andreina
Departamentos de Obstetricia y Ginecología, Anatomía Patológica y de Pediatría, Escuela de Medicina Pontificia Universidad Católica de Chile.
Rev Med Chil. 2003 Jan;131(1):71-6.
A six years old girl consulted due to mammary development. On physical examination, clitoris enlargement and a tumor localized in the abdominal-pelvic region were observed. Hormonal study disclosed elevated testosterone and estradiol levels. On exploratory laparotomy, a right ovarian tumor was observed and a right salpingooophorectomy was performed. The contemporary biopsy informed a disgerminoma, leading to a surgical staging of the tumor. The definitive pathological diagnosis was a juvenile granular cell tumor, limited to the ovary. In the postoperative period, estradiol and testosterone levels returned to normal values and the pseudopuberty reverted. The patient did not receive adjuvant treatment and after three years of follow up, there is no evidence of tumor recidivism.
一名六岁女孩因乳腺发育前来咨询。体格检查发现阴蒂增大，且在腹盆腔区域有一个肿瘤。激素研究显示睾酮和雌二醇水平升高。在剖腹探查术中，发现右侧卵巢肿瘤并进行了右侧输卵管卵巢切除术。当时的活检提示为无性细胞瘤，从而对肿瘤进行了手术分期。最终病理诊断为幼年型颗粒细胞瘤，局限于卵巢。术后，雌二醇和睾酮水平恢复正常，假性性早熟消退。患者未接受辅助治疗，经过三年随访，没有肿瘤复发的迹象。
