由颗粒-卵泡膜细胞瘤引起的同性性早熟假性青春期中雌激素的来源。
Origin of estrogen in isosexual precocious pseudopuberty due to a granulosa-theca cell tumor.
作者信息
Madden J D, MacDonald P C
出版信息
Obstet Gynecol. 1978 Feb;51(2):210-3.
PMID:202898
Abstract
The purpose of the present study was to quantify the rates of production and to define the mechanism(s) or origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17beta synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen.
摘要
本研究的目的是对一名3岁半患有由卵巢颗粒-卵泡膜细胞瘤引起的同性性早熟假性青春期的女孩的性类固醇激素生成速率进行量化，并确定其生成机制或来源。结果表明，高雌激素血症主要是由于肿瘤重新合成并分泌雌二醇-17β所致，但该肿瘤在体内也能够将血浆中的C19前体激素芳香化为雌激素。
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