某些五环三萜酸及其脂肪酸酯类似物的拒食活性。

Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues.

作者信息

Mallavadhani Uppuluri V, Mahapatra Anita, Raja S Sabitha, Manjula C

机构信息

Forest and Marine Products Department, Natural Resources Division, Regional Research Laboratory (CSIR), Bhubaneswar-751 013, Orissa, India.

出版信息

J Agric Food Chem. 2003 Mar 26;51(7):1952-5. doi: 10.1021/jf020691d.

DOI:10.1021/jf020691d

PMID:12643657

Abstract

The 3-O-fatty acid ester derivatives (C(12)-C(18)) of two pentacyclic triterpenic acids, ursolic acid and oleanolic acid, were synthesized under mild esterification conditions in excellent yields (80-85%) and screened for their antifeedant activity, together with the parent acids, against the agricultural pest tobacco caterpillar larvae (Spodoptera litura F) in a no-choice laboratory study. The Urs-12-ene-28-carboxy-3beta-octadecanoate and olean-12-ene-28-carboxy-3beta-hexadecanoate were found to exhibit exceptionally potent antifeedant activities at 50 microg/cm(2) concentration, even after 48 h.

摘要

在温和的酯化条件下，以高产率（80 - 85%）合成了两种五环三萜酸——熊果酸和齐墩果酸的3 - O - 脂肪酸酯衍生物（C(12)-C(18)），并在一项无选择的实验室研究中，与母体酸一起针对农业害虫烟草夜蛾幼虫（斜纹夜蛾F）进行了拒食活性筛选。结果发现，熊果 - 12 - 烯 - 28 - 羧基 - 3β - 十八烷酸酯和齐墩果 - 12 - 烯 - 28 - 羧基 - 3β - 十六烷酸酯即使在48小时后，在50微克/平方厘米的浓度下仍表现出极强的拒食活性。