Rokot Natasya Trivena, Kairupan Timothy Sean, Cheng Kai-Chun, Runtuwene Joshua, Kapantow Nova Hellen, Amitani Marie, Morinaga Akinori, Amitani Haruka, Asakawa Akihiro, Inui Akio
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan; Faculty of Medicine, Sam Ratulangi University, Manado 95115, Indonesia.
Evid Based Complement Alternat Med. 2016;2016:2614742. doi: 10.1155/2016/2614742. Epub 2016 Aug 18.
Ginseng, a perennial plant belonging to the Panax genus of the Araliaceae family, has been used in China, Korea, and Japan as a traditional herbal medicine for thousands of years. Ginseng is recorded to have exhibited a wide variety of beneficial pharmacological effects and has become a popular and worldwide known health supplement and drug. The protective effects of ginseng on central nervous system are discussed in this review. Ginseng species and ginsenosides and their intestinal metabolism and bioavailability are concisely introduced. The molecular mechanisms of the effects of ginseng on central nervous system, mainly focused on the neuroprotection properties of ginseng, memory, and learning enhanced properties, and the effects on neurodegenerative disorders are presented. Thus, ginseng and its constituents are of potential merits in the treatment of cerebral disorders.
人参是五加科人参属的多年生植物，在中国、韩国和日本作为传统草药使用了数千年。据记载，人参具有多种有益的药理作用，已成为一种广受欢迎且闻名全球的健康补充剂和药物。本综述讨论了人参对中枢神经系统的保护作用，并简要介绍了人参的种类、人参皂苷及其肠道代谢和生物利用度。阐述了人参对中枢神经系统作用的分子机制，主要聚焦于人参的神经保护特性、增强记忆和学习的特性以及对神经退行性疾病的影响。因此，人参及其成分在治疗脑部疾病方面具有潜在价值。
