Campbell B J, Reinhold J G, Cannell J J, Nourmand I
Pahlavi Med J. 1976 Jan;7(1):1-17.
The ability to adapt to a large daily intake of unleavened bread made from wheaten wholemeals of high extraction rate was examined in two young Americans who had not previously consumed fiber, phytate-, and phosphate-rich bread of this type. Adaptation was evaluated by comparing balances of zinc, calcium, magnesium, and phosphorus for a 12 day period after ten days of bread consumption with those during a similar period after 50 days and also by observing changes in blood composition during this period of bread consumption. Significantly negative balances of zinc, magnesium and phosphorus were observed in the initial period. However, all had become positive or nearly so after 50 days. By contrast, calcium balances which were also negative during the initial period remained negative at the end of the study. Plasma calcium and zinc concentrations had declined to low normal or subnormal values at this time. The failure to overcome the disturbing effects of consumption of wholemeal bread upon calcium metabolism occurred despite daily exposure to sunshine for many hours under conditions favorable for Vitamin D biosynthesis.
对两名此前未食用过此类富含纤维、植酸盐和磷酸盐的高提取率全麦无酵面包的美国年轻人，研究了他们适应大量食用这种面包的能力。适应情况通过比较食用面包10天后12天内锌、钙、镁和磷的平衡情况与50天后相似时间段内的平衡情况来评估，同时也通过观察食用面包期间血液成分的变化来评估。在初始阶段，观察到锌、镁和磷的平衡显著为负。然而，50天后所有这些平衡都变为正值或接近正值。相比之下，初始阶段也为负的钙平衡在研究结束时仍为负。此时血浆钙和锌浓度已降至低正常或低于正常水平。尽管在有利于维生素D生物合成的条件下每天接受数小时日照，但仍未能克服食用全麦面包对钙代谢的干扰作用。
