抗酶是果蝇生殖系中性别致死基因的一个靶点，并且似乎在刺猬信号通路下游发挥作用，以调控性别致死基因和细胞周期蛋白B。
Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B.
作者信息
Vied Cynthia, Halachmi Naomi, Salzberg Adi, Horabin Jamila I
机构信息
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA.
出版信息
Dev Biol. 2003 Jan 15;253(2):214-29. doi: 10.1016/s0012-1606(02)00012-x.
The sex determination master switch, Sex-lethal, has been shown to regulate the mitosis of early germ cells in Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment aimed at identifying targets of Sex-lethal in early germ cells, the RNA encoded by gutfeeling, the Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated. gutfeeling interacts genetically with Sex-lethal. It is not only a target of Sex-lethal, but also appears to regulate the nuclear entry and overall levels of Sex-lethal in early germ cells. This regulation of Sex-lethal by gutfeeling appears to occur downstream of the Hedgehog signal. We also show that Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis.
性别决定主控基因“性致死”已被证明可调控黑腹果蝇早期生殖细胞的有丝分裂。“性致死”是一种RNA结合蛋白，可调节体细胞中特定靶标的剪接和翻译，但生殖系靶标尚不清楚。在一项旨在鉴定早期生殖细胞中“性致死”靶标的实验中，分离出了鸟氨酸脱羧酶抗酶的果蝇同源物“直觉”所编码的RNA。“直觉”与“性致死”存在遗传相互作用。它不仅是“性致死”的一个靶标，而且似乎还调节早期生殖细胞中“性致死”的核内进入及总体水平。“直觉”对“性致死”的这种调节似乎发生在刺猬信号的下游。我们还表明，刺猬、直觉和性致死共同作用来调节细胞周期蛋白B，从而在性致死和有丝分裂之间建立了联系。
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