Hsu Hsiang-Hao, Chang Chiz-Tzung, Lin Ja-Liang
Poison Center and Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
J Toxicol Clin Toxicol. 2003;41(1):87-90. doi: 10.1081/clt-120018278.
Paraquat poisoning is the most common cause of fatal herbicide intoxication, mostly through oral ingestion. This work reports two cases of death following intravenous paraquat injection. The clinical courses of the two cases were fulminated and fatal. Toxic symptoms and severe organ function impairment developed soon after paraquat injection. Timely treatment with activated charcoal hemoperfusion with pulse steroid and cyclophosphamide was attempted in both cases; however, both cases died within five days owing to multiple organ failure. In cases of intravenous paraquat intoxication, toxic signs develop more quicker than with oral ingestion. The prognosis of intravenous paraquat intoxication is extremely poor.
百草枯中毒是除草剂中毒致死的最常见原因，主要通过口服摄入。本文报告了两例静脉注射百草枯后的死亡病例。两例的临床病程均呈暴发性且致命。百草枯注射后不久即出现中毒症状和严重器官功能损害。两例均尝试及时采用活性炭血液灌流联合脉冲式类固醇及环磷酰胺进行治疗；然而，两例均因多器官衰竭在五天内死亡。在静脉注射百草枯中毒的病例中，中毒体征比口服摄入时出现得更快。静脉注射百草枯中毒的预后极差。
