Mahoudeau J A, Bricaire H
Nouv Presse Med. 1976 Mar 20;5(12):767-70.
In normal adult male, the intra-muscular hCG-test (5000 I.U. X 3) results in a progressive rise of plasma testosterone and dihydrotestosterone, and in a sharp increase of plasma estradiol followed by a decrease although th hCG stimulation is maintained. In testicular dysgenesis, the testosterone and estradiol responses are variable. In adult male gonadotropin deficiency, basal testosterone is always very low, and rises strongly, under hCG-test, only when previous and recent (less than 10 years) exposure to endogenous or exogenous gonadotropin had induced virilization ; by contrast the defective response of estradiol in all cases provides a reliable estimate of the actual gonadotropin deficiency.
在正常成年男性中，肌内注射人绒毛膜促性腺激素试验（5000国际单位×3）会导致血浆睾酮和双氢睾酮逐渐升高，以及血浆雌二醇急剧增加，随后尽管持续进行人绒毛膜促性腺激素刺激，其水平仍会下降。在睾丸发育不全时，睾酮和雌二醇的反应各不相同。在成年男性促性腺激素缺乏症中，基础睾酮水平始终非常低，在人绒毛膜促性腺激素试验中，只有当既往（小于10年）和近期暴露于内源性或外源性促性腺激素诱导了男性化时，睾酮水平才会显著升高；相比之下，在所有病例中雌二醇的反应缺陷可提供对实际促性腺激素缺乏的可靠评估。
