Inskip Peter D, Tarone Robert E, Brenner Alina V, Fine Howard A, Black Peter M, Shapiro William R, Selker Robert G, Linet Martha S
Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Cancer Epidemiol Biomarkers Prev. 2003 Mar;12(3):223-5.
The objective of this study was to evaluate the relation between handedness, and the risk of malignant and benign brain tumors. Handedness has been hypothesized to serve as a behavioral marker of prenatal hormonal exposures or other factors that influence subsequent cancer risk. A case-control study was conducted at hospitals in three United States cities between 1994 and 1998. The cases were adult patients newly diagnosed with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96), and the 799 frequency-matched controls were patients admitted to the same hospitals for a variety of nonmalignant conditions. Handedness was determined by interview. Unconditional logistic regression was used to estimate odds ratios (ORs) and calculate 95% confidence intervals (CIs). Persons who described themselves as left-handed or ambidextrous appeared to be at reduced risk of glioma relative to those who described themselves as right-handed (OR, 0.7; 95% CI, 0.5-0.9). The association was similar for men and women, and for left-sided and right-sided tumors. Neither meningioma (OR, 0.9; CI, 0.6-1.5) nor acoustic neuroma (OR, 0.9; CI, 0.5-1.7) showed significant associations with handedness. These findings require confirmation but raise the possibility that early neurodevelopmental events or genetic factors related to handedness also influence the risk of glioma among adults.
本研究的目的是评估用手习惯与恶性和良性脑肿瘤风险之间的关系。有人提出，用手习惯可作为产前激素暴露或其他影响后续癌症风险的因素的行为标志。1994年至1998年期间，在美国三个城市的医院开展了一项病例对照研究。病例为新诊断为神经胶质瘤（n = 489）、脑膜瘤（n = 197）或听神经瘤（n = 96）的成年患者，799名频率匹配的对照为因各种非恶性疾病入住同一家医院的患者。通过访谈确定用手习惯。采用无条件逻辑回归来估计比值比（OR）并计算95%置信区间（CI）。相对于那些称自己为右利手的人，那些称自己为左利手或双手灵巧的人患神经胶质瘤的风险似乎降低了（OR，0.7；95%CI，0.5 - 0.9）。男性和女性、左侧和右侧肿瘤的关联相似。脑膜瘤（OR，0.9；CI，0.6 - 1.5）和听神经瘤（OR，0.9；CI，0.5 - 1.7）与用手习惯均未显示出显著关联。这些发现需要进一步证实，但增加了这样一种可能性，即与用手习惯相关的早期神经发育事件或遗传因素也会影响成年人患神经胶质瘤的风险。
