Hardell L, Näsman A, Påhlson A, Hallquist A, Hansson Mild K
Orebro Medical Centre, SE-701 85 Orebro, Sweden.
Int J Oncol. 1999 Jul;15(1):113-6.
The use of cellular telephones has increased dramatically during the 1990's in the world. In the 1980's the analogue NMT system was used whereas the digital GSM system was introduced in early 1990's and is now the preferred system. Case reports of brain tumours in users initiated this case-control study on brain tumours and use of cellular telephones. Also other exposures were assessed. All cases, both males and females, with histopathologically verified brain tumour living in Uppsala-Orebro region (1994-96) and Stockholm region (1995-96) aged 20-80 at the time of diagnosis and alive at start of the study were included, 233 in total. Two controls to each case were selected from the Swedish Population Register matched for sex, age and study region. Exposure was assessed by questionnaires supplemented over the phone. The analyses were based on answers from 209 (90%) cases and 425 (91%) controls. Use of cellular telephone gave odds ratio (OR) = 0.98 with 95% confidence interval (CI) = 0. 69-1.41. For the digital GSM system OR = 0.97, CI = 0.61-1.56 and for the analogue NMT system OR = 0.94, CI = 0.62-1.44 were calculated. Dose-response analysis and using different tumour induction periods gave similar results. Non-significantly increased risk was found for tumour in the temporal or occipital lobe on the same side as a cellular phone had been used, right side OR = 2.45, CI = 0.78-7.76, left side OR = 2.40, CI = 0.52-10.9 Increased risk was found only for use of the NMT system. For GSM use the observation time is still too short for definite conclusions. An increased risk for brain tumour in the anatomical area close to the use of a cellular telephone should be especially studied in the future.
20世纪90年代，全球手机使用量急剧增加。20世纪80年代使用的是模拟NMT系统，而数字GSM系统于20世纪90年代初推出，如今已成为首选系统。手机使用者中脑肿瘤的病例报告引发了这项关于脑肿瘤与手机使用的病例对照研究。同时还评估了其他暴露因素。纳入了所有在乌普萨拉 - 厄勒布鲁地区（1994 - 1996年）和斯德哥尔摩地区（1995 - 1996年）居住、诊断时年龄在20 - 80岁且研究开始时仍存活的经组织病理学证实患有脑肿瘤的病例，男女皆有，共计233例。从瑞典人口登记册中为每个病例选取两名性别、年龄和研究地区匹配的对照。通过电话补充的问卷来评估暴露情况。分析基于209例（90%）病例和425例（91%）对照的回答。使用手机的优势比（OR） = 0.98，95%置信区间（CI） = 0.69 - 1.41。对于数字GSM系统，OR = 0.97，CI = 0.61 - 1.56；对于模拟NMT系统，计算得出OR = 0.94，CI = 0.62 - 1.44。剂量反应分析以及使用不同的肿瘤诱导期得出了相似的结果。在使用手机同侧的颞叶或枕叶发现肿瘤风险有非显著性增加，右侧OR = 2.45，CI = 0.78 - 7.76，左侧OR = 2.40，CI = 0.52 - 10.9。仅在使用NMT系统时发现风险增加。对于GSM系统，观察时间仍太短，无法得出明确结论。未来应特别研究在靠近使用手机的解剖区域脑肿瘤风险增加的情况。
